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国家“青年千人计划”

姓名 

游淳 

性别 

男 

专家类别 

国家青年千人计划

天津市青年千人计划 

职称 

研究员 

学历 

博士 

电话 

 

传真 

 

电子邮件 

you_c(AT)tib.cas.cn 

地址 

天津空港经济区西七道32 

邮编 

300308 

 

简历   

  1、教育经历 

  2003.9-2009.6,复旦大学,微生物遗传学, 博士 

  1999.9-2003.6复旦大学,生物科学,学士 

  2、工作经历 

  2016.3-至今,中国科学院天津工业生物技术研究所,研究员 

  2015.3-2016.3美国, Cell Free Bioinnovations Inc. 首席科学家 

  2012.4-2016.3美国弗吉尼亚理工大学,高级科研助理 

    2010.4-2012.4,美国弗吉尼亚理工大学,博士后 

研究方向    

  体外合成生物体系是新兴的生物制造平台,相对于传统的微生物制造平台,体外合成生物体系具有很多优点,例如产品得率高,反应速度快,反应条件广谱等。本研究组致力于构建和优化体外合成生物体系,生产粮食,能源,大宗化学品等。 

获奖情况  

  2012年度高等学校科学研究优秀成果奖二等奖 

  2013上海市科学技术奖二等奖

代表性学术成果

  1、论文    

   1)  YOU C, Chen HG, Myung S, Sathisuksanoh N, Ma H, Zhang XZ, Li JY, Zhang Y-HP*.2013. Enzymatic transformation of non-food biomass to starch. Proceedings of the National Academy of Sciences of the USA. 110: 7182-7189.  (Highlighted by Science magazine)  

   2)  YOU C, Myung S, Zhang Y-HP*. 2012. Facilitated substrate channeling in a self-assembled trifunctional enzyme complex. Angewandte Chemie International Edition.51: 8787-8790  

   3)  YOU C, Zhang X-Z , Sathitsuksanoh N , Lynd LR, Zhang Y-HP*. 2012. Enhanced microbial cellulose utilization of recalcitrant cellulose by an ex vivo cellulosome-microbe complex. Applied and Environmental Microbiology 78(5):1437-1444  

   4)  YOU C, Zhang X-Z, Zhang Y-HP*. 2012. Simple Cloning via direct transformation of PCR product (DNA multimer) to Escherichia coli and Bacillus subtilisApplied and Environmental Microbiology 78(5):1593-1595  

   5)  YOU CZhang Y-HP*. 2012. Easy preparation of a large-size random gene mutagenesis library in Escherichia coliAnalytical Biochemistry 428:7-12  

   6)  YOU C, Zhang X-Z, Zhang Y-HP*2012. Mini-scaffoldin enhanced mini-cellulosome hydrolysis performance on low-accessibility cellulose (Avicel) more than on high-accessibility amorphous cellulose. Biochemical Engineering Journal 63:57-65  

   7)  YOU CZhang Y-HP*. 2013. Self-assembly of synthetic metabolons through synthetic scaffoldins: single-step purification, co-immobilization, and substrate channeling. ACS Synthetic Biology 2:102-110, (cover page).  

   8)  YOU CZhang Y-HP*. 2014. Annexation of a high-activity rate-limiting enzyme in a synthetic three-enzyme complex greatly decreases the degree of substrate channeling. ACS Synthetic Biology, 3(6): 380-386   

   9)  YOU C, Huang Q, Xue HP, Xu Y, Lu H *. 2010. Potential hydrophobic interaction between two cysteines in interior hydrophobic region improves thermostability of a family 11 xylanase from Neocallimastix patriciarum. Biotechnology and Bioengineering 105(5):861-70  

   10) Rollin JA, Martin del Campo J, Myung S, Sun F, YOU C, Bakovic A, Castro R, Chandrayan SK, Wu CH, Adams  MWW, Senger RS, Zhang Y-HP, 2015. High-yield hydrogen production from biomass by in vitro metabolic engineering: Mixed sugars coutilization and kinetic modeling. Proceedings of the National Academy of Sciences 112 (16), 4964-4969.  

   11) Zhu ZG, Tam TK, Sun FF, YOU CZhang Y-HP*. 2014. A high-energy-density sugar biobattery based on a synthetic enzymatic pathway. Nature Communications. 5: 3026,  

   12) Martin del Campo JS, Rollin JR, Myung S, YOU C, Chandrayan S, Patiño R,  Adams MWW, Zhang Y-HP*2013. Dihydrogen production from xylose and water mediated by synthetic cascade enzymes. Angewandte Chemie International Edition 52:4587-4590,  

   13) Myung S, YOU CZhang Y-HP*. 2013. Recyclable cellulose-containing magnetic nanoparticles: immobilization of cellulose-binding module-tagged proteins and synthetic metabolon featuring substrate channeling. Journal of Materials Chemistry B. 1:4419-4427.  

   14) Martin del Campo JS, YOU C, Kim J-E, Patiño R, Zhang Y-HP*. 2013. Discovery and characterization of a novel ATP/polyphosphate xylulokinase from a hyperthermophilic bacterium Thermotoga maritimaJournal of Industrial Microbiology and Biotechnology 40:661-669.  

   15) Myung S, Rollin J, YOU C, Sun F, Chandrayan S, Adams MWW, Zhang Y-HP. 2014. In vitro metabolic engineering of hydrogen production at theoretical yield from sucrose. Metabolic Engineering 24(0):70-77.   

   16) Peng Q, YOU C, Zhang Y-HP*, 2014, One-Pot Enzymatic Conversion of Sucrose to Synthetic Amylose by using Enzyme Cascades. ACS Catalysis. 4:1311-1317.   

   17) Gao SH, YOU C, Renneckar S, Bao J, Zhang Y-HP*. 2014. New insights into enzymatic hydrolysis of heterogeneous cellulose by using CBM3-containing GFP and CBM17-containing CFP. Biotechnology for Biofuels.  7(1):24  

   18) Xue HP, Zhou JG, YOU C, Huang Q, Lu H *. 2012. Amino acid substitutions in the N-terminus, cord and α-helix domains improved the thermostability of a family 11 xylanase XynR8. Journal of Industrial Microbiology and Biotechnology 39:1279-1288   

   19) Zhou JG, Bao L, Chang L, Liu Z, YOU C, Lu H *. 2012. Beta-xylosidase activity of a GH3 glucosidase/xylosidase from yak rumen metagenome promotes the enzymatic degradation of hemicellulosic xylans. Letters in Applied Microbiology 54:79-87   

   20) Zhang Y-HP*, Myung S, YOU C, Zhu ZG, Rollin J. 2011. Toward low-cost biomanufacturing through cell-free synthetic biology: bottom-up design. Journal of Materials Chemistry 21: 18877-18886  

  2、专著  

   1)  YOU CZhang Y-HP*. 2013. Cell-free biosystems for biomanufacturing. Advances in Biochemical Engineering/Biotechnology 131:89-119 (Invited Book Chapter).  

   2)  YOU CZhang Y-HP*. 2014. Simple cloning and DNA assembly in E. coli by prolonged overlap extension PCR. Methods of Molecular Biology 1116; (invited book Chapter)  

   3)  Zhang Y-HP*, YOU C, Chen HG, Feng RL. 2012. Surpassing photosynthesis: high-efficiency and scalable CO2 utilization through artificial photosynthesis. ACS Symposium Series 1097: 275-292 (Recent Advances in Post-Combustion CO2 Capture Chemistry), Oxford University Press, UK (Book Chapter)  

   4)  Jandt U, YOU CZhang Y-HP, Zeng A-P*2013. Compartmentation and metabolic channeling: practical and modeling aspects for multienzymatic biosynthesis. Advances in Biochemical Engineering/Biotechnology 137:41-65,(Invited Book Chapter).  

  3、专利  

   1)张以恒,游淳。肌醇的制备方法,游淳,申请号:201510184621.4  

   2吕红,游淳,黄强。一种耐高温耐强碱的木聚糖酶改良基因及其基因工程菌株及其制备方法,专利号:CN200810200060.2 

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