副研究员/高级工程师
徐桐

徐桐


  • 职  称:副研究员
  • 学  历:博士研究生
  • 通讯地址:天津市空港经济区西七道32号
  • 邮政编码:300308
  • 电子邮件:xutong@tib.cas.cn
  • 部  门:体外合成生物学中心

简历

1. 教育经历

2015.9-2019.6,东北农业大学,博士,微生物学

2011.9-2015.6,东北农业大学,学士,生物科学(理科试验班)

2. 工作经历

2025.9-今,中国科学院天津工业生物技术研究所,副研究员

2019.7-2025.6,中国科学院微生物研究所,博士后

研究方向

基因编辑工具开发;遗传操作系统;高通量基因筛选;定向进化;突变体库构建;合成生物学;底盘细胞工程;功能基因挖掘

代表成果

(1)Xu, Tong; Li, Hao; Zhang, Shengjie; Wang, Jinhong; Hewage, Richard; Guo, Feng; Han, Yiran; Kondrasheva, Kseniya; Han. Jing*; Xiang, Hua*;论文Development of an endogenous Type I-E CRISPR-Cas-based gene editing tool for Halomonas nigrificans X339: Applications in enhancing poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production; Chemical Engineering Journal; 2025; 520:166147.

(2) Xu, Tong; Mitra, Ruchira; Tan, Dan; Li, Zhengjun; Zhou, Cheng; Chen, Tao; Xie, Zhengwei; Han, Jing; Utilization of gene manipulation system for advancing the biotechnological potential of halophiles: A review, Biotechnology Advances, 2024, 70: 108302

(3) Xu, Tong; Li, Hao; Zhang, Shengjie; Xue, Qiong; Hewage, Richard; Wang, Jinhong; Guo, Feng; Zhao, Dahe; Ai, Guomin; Kahramon, Davranov; Xiang, Hua; Han, Jing; Production of polyhydroxybutyrate from wheat straw hydrolysate using a low-salt requiring and alkaliphilic Halomonas nigrificans X339 under non-sterile open condition, Bioresource Technology, 2025, 132276

(4) Xu, Tong; Chen, Junyu; Mitra, Ruchira; Lin, Lin; Xie, Zhengwei; Chen, Guo-Qiang; Xiang, Hua; Han, Jing; Deficiency of exopolysaccharides and O-antigen makes Halomonas bluephagenesis self-flocculating and amenable to electrotransformation, Communications biology, 2022, 5(1): 623

(5) Xu, Tong; Chen, Huiwen; Li, Jincheng; Hong, Shan; Shao, Li; Zheng, Xiutao; Zou, Qiao; Wang, Yuting; Guo, Sijia; Jiang, Juquan; Implications for Cation Selectivity and Evolution by a Novel Cation Diffusion Facilitator Family Member From the Moderate Halophile Planococcus dechangensis, Frontiers in Microbiology, 2019, 10: 607

(6) Shao, Li; Xu, Tong; Zheng, Xiutao; Shao, Dandan; Zhang, Haitao; Chen, Huiwen; Zhang, Zhenglai; Yan, Mingxue; Abdel-Motaal, Heba; Jiang, Juquan; A novel three-TMH Na+/H+ antiporter and the functional role of its oligomerization, Journal of Molecular Biology, 2021, 433(2): 166730

(7) Mitra, Ruchira; Xu, Tong; Xiang, Hua; Han, Jing; Current developments on polyhydroxyalkanoates synthesis by using halophiles as a promising cell factory, Microbial Cell Factories, 2020, 19(1): 86

(8) Mitra, Ruchira; Xu, Tong; Chen, Guo-Qiang; Xiang, Hua; Han, Jing; An updated overview on the regulatory circuits of polyhydroxyalkanoates synthesis, Microbial Biotechnology, 2021, 15(5): 1446-1470.