王钰----中国科学院天津工业生物技术研究所

人才队伍

国家优秀青年基金获得者

王钰

职　　称：研究员
学　　历：博士研究生
导师类别：博士生导师
通讯地址：天津市空港经济区西七道32号
电　　话：022-24828709
邮政编码：300308
电子邮件：wang_y@tib.cas.cn
部　　门：有机一碳生物代谢与转化研究组

简历

1. 教育经历

2012.09-2016.03，上海交通大学生命科学技术学院，博士研究生，生物学，理学博士

2015.09-2015.10，德国汉堡工业大学，交流访问

2009.09-2012.06，山东大学生命科学学院，硕士研究生，微生物学，理学硕士

2005.09-2009.06，山东大学生命科学学院，本科，生物技术，理学学士

2. 工作经历

2022.06-至今，中国科学院天津工业生物技术研究所，研究员

2018.11-2022.06，中国科学院天津工业生物技术研究所，副研究员

2016.04-2018.11，中国科学院天津工业生物技术研究所，助理研究员

主持国家重点研发计划“合成生物学”重点专项项目、国家优秀青年基金、天津市杰出青年科学基金等项目；以第一或通讯作者在Nat. Commun.、Trends Biotechnol.、Nucleic Acids Res.、Metab. Eng.、ACS Synth. Biol.等期刊发表论文50余篇，申请专利30余项；入选中国科学院特聘研究员、中国科学院青年创新促进会、《麻省理工科技评论》亚太区“35岁以下科技创新35人”、“伦世仪教育基金”杰出青年学者等，曾获日本生物工学会DaSilva Award和明治生命科学奖等荣誉；兼任中国青年科技工作者协会生命科学与医药专委会委员、中国生物工程学会青年工作委员会和一碳生物技术专委会委员、中国遗传学会微生物遗传专委会委员、中国化工学会生物化工青年委员会委员、天津微生物学会理事、天津市青联常委、中国科学院青年创新促进会生命分会副会长、Trends Biotechnol.等期刊编委。

研究方向

王钰研究员目前担任低碳合成工程生物学全国重点实验室副主任、有机一碳生物代谢与转化研究组组长，主要从事工业微生物的基因编辑育种和一碳原料的生物转化研究，针对甲醇芽孢杆菌、谷氨酸棒杆菌等具有优良工业应用属性的微生物，开展基因组编辑、人工进化、代谢重编程等合成生物学研究，设计创制工程微生物菌种，实现甲醇等一碳原料和非粮原料合成材料化学品、氨基酸和单细胞蛋白等大宗生物基产品。

获奖及荣誉

2022，《麻省理工科技评论》亚太区“35岁以下科技创新35人”

2022，日本生物工学会DaSilva Award

2022，“伦世仪教育基金”杰出青年学者

2021，中国化工学会生物化工专业委员会第四届青年学者论坛优秀报告奖

2020，天津市优秀科技志愿者

2020，天津市滨海新区科普大使

2018，中国微生物学会学术年会主旨报告奖

2016，上海市高等学校优秀毕业生

2014，明治生命科学奖

代表成果

完整的论文发表记录：https://orcid.org/0000-0002-0957-9245

1. Liu P, Yuan Q, Yang X, Wang Q, Chang T, Bi Y, Wu P, Zhang T, Yang J, Guo S, Xue C, Zheng Z, Xin B, Ma H, Wang Y*. 2025. A synthetic biology toolkit for interrogating plasmid-dependent methylotrophy and enhancing methanol-based biosynthesis of Bacillus methanolicus. bioRxiv, https://www.biorxiv.org/content/10.1101/2025.05.06.652373v1.

2. Yang X, Zheng Z*, Wang Y*. 2025. Bacillus methanolicus: an emerging chassis for low-carbon biomanufacturing. Trends Biotechnol, 43, 274–277.

3. Liu J, Zhao X, Cheng H, Guo Y, Ni X, Wang L, Sun G, Wen X, Chen J, Wang J, An J, Guo X, Shi Z, Li H, Wang R, Zhao M, Liao X, Wang Y*, Zheng P*, Wang M*, Sun J. 2025. Comprehensive screening of industrially relevant components at genome scale using a high-quality gene overexpression collection of Corynebacterium glutamicum. Trends Biotechnol, 43, 220–247.

4. Pu W, Feng J, Chen J, Liu J, Guo X, Wang L, Zhao X, Cai N, Zhou W, Wang Y*, Zheng P*, Sun J. 2025. Engineering of L-threonine and L-proline biosensors by directed evolution of transcriptional regulator SerR and application for high-throughput screening. Bioresour Bioprocess, 12, 4.

5. Yang J, Zheng P, Li S*, Wang Y*, Sun J*. 2025. Sustainable production of chemicals from methanol via biological routes, Comprehensive Methanol Science, First Edition, 4, 488-509.

6. Cheng G, Sun H, Wang Q, Yang J, Qiao J, Zhong C, Cai T*, Wang Y*. 2024. Scanning the active center of formolase to identify key residues for enhanced C1 to C3 bioconversion. Bioresour Bioprocess, 11, 48.

7. Yang J, Fan L, Cheng G, Cai T, Sun J, Zheng P*, Li S*, Wang Y*. 2024. Engineering of cofactor preference and catalytic activity of methanol dehydrogenase by growth-coupled directed evolution. Green Carbon, 2, 242–251.

8. Xin B, Zhong C*, Wang Y*. 2023. Integrating the marine carbon resource mannitol into biomanufacturing. Trends Biotechnol, 41:745–749.

9. Cai N, Chen J, Gao N, Ni X, Lei Y, Pu W, Wang L, Che B, Fan L, Zhou W, Feng J, Wang Y*, Zheng P*, Sun J. 2023. Engineering of the DNA replication and repair machinery to develop binary mutators for rapid genome evolution of Corynebacterium glutamicum. Nucleic Acids Res, 51, 8623–8642.

10. Sun L, Zheng P, Sun J, Wendisch VF, Wang Y*. 2023. Genome-scale CRISPRi screening: A powerful tool in engineering microbiology. Eng Microbiol, 3, 100089.

11. Zhou Y, Chen J, Pu W, Cai N, Che B, Yang J, Wang M, Zhong S, Zuo X, Wang D, Wang Y*, Zheng P*, Sun J. 2023. Development of a growth-coupled selection platform for directed evolution of heme biosynthetic enzymes in Corynebacterium glutamicum. Front Bioeng Biotechnol, 11, 1236118.

12. Qian J, Fan L, Yang J, Feng J, Gao N, Cheng G, Pu W, Zhou W, Cai T, Li S, Zheng P, Sun J, Wang D*, Wang Y*. 2023. Directed evolution of a neutrophilic and mesophilic methanol dehydrogenase based on high-throughput and accurate measurement of formaldehyde. Synth Syst Biotechnol, 8, 386–395.

13. Pu W, Chen J, Zhou Y, Qiu H, Shi T, Zhou W, Guo X, Cai N, Tan Z, Liu J, Feng J, Wang Y*, Zheng P*, Sun J. 2023. Systems metabolic engineering of Escherichia coli for hyper-production of 5‑aminolevulinic acid. Biotechnol Biofuels Bioprod, 16, 31.

14. Pu W, Chen J, Liu P, Shen J, Cai N, Liu B, Lei Y, Wang L, Ni X, Zhang J, Liu J, Zhou Y, Zhou W, Ma H, Wang Y*, Zheng P*, Sun J. 2023. Directed evolution of linker helix as an efficient strategy for engineering LysR-type transcriptional regulators as whole-cell biosensors. Biosens Bioelectron, 222, 115004.

15. Liu Y, Liu Y, Zheng P, Wang Y*, Wang M*. 2023. Cytosine base editing in Bacteria, p 219–231. In Bae S, Song B (ed), Base Editors: Methods and Protocols, doi:10.1007/978-1-0716-2879-9_17. Springer US, New York, NY.

16. Liu J, Liu M, Shi T, Sun G, Gao N, Zhao X, Guo X, Ni X, Yuan Q, Feng J, Liu Z, Guo Y, Chen J, Wang Y*, Zheng P*, Sun J. 2022. CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction. Nat Commun, 13, 891 (Editors’ highlights and Focus article on biotechnology and method).

17. Wang Y, Zhao D, Sun L, Wang J, Fan L, Cheng G, Zhang Z, Ni X, Feng J, Wang M, Zheng P*, Bi C*, Zhang X*, Sun J. 2022. Engineering of the translesion DNA synthesis pathway enables controllable C-to-G and C-to-A base editing in Corynebacterium glutamicum. ACS Synth Biol, 11, 3368–3378.

18. Chen J, Wang Y*, Zheng P*, Sun J. 2022. Engineering synthetic auxotrophs for growth-coupled directed protein evolution. Trends Biotechnol, 40, 773–776.

19. Wang Y*, Zheng P, Sun J*. 2022. Developing synthetic methylotrophs by metabolic engineering-guided adaptive laboratory evolution. Adv Biochem Eng Biotechnol, 180, 127–148.

20. Wang Y*, Cheng H, Liu Y, Liu Y, Wen X, Zhang K, Ni X, Gao N, Fan L, Zhang Z, Liu J, Chen J, Wang L, Guo Y, Zheng P*, Wang M*, Sun J, Ma Y. 2021. In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nat Commun, 12, 678 (Editors’ highlights and Focus article on biotechnology and method).

21. Wang Y*, Liu Y, Zheng P, Sun J, Wang M*. 2021. Microbial base editing: a powerful emerging technology for microbial genome engineering. Trends Biotechnol, 39, 165–180 (Selected cover and free featured article).

22. Zhang Z, Wang Y*, Zheng P*, Sun J. 2021. Promoting lignin valorization by coping with toxic C1 byproducts. Trends Biotechnol, 39, 331–335.

23. Fan L, Wang Y*, Qian J, Gao N, Zhang Z, Ni X, Sun L, Yuan Q, Zheng P*, Sun J. 2021. Transcriptome analysis reveals the roles of nitrogen metabolism and sedoheptulose bisphosphatase pathway in methanol-dependent growth of Corynebacterium glutamicum. Microb Biotechnol, 14, 1797–1808.