2007年毕业于中国科学院海洋研究所（博士），随后加入聊城大学工作，历任副教授、食品科学系系主任，2011年加入中国科学院天津工业生物技术研究所，现任研究员、博士生导师、工业生物系统工程研究组组长，2015.8-2016.7期间到美国华盛顿州立大学访问交流。担任COMSATS工业生物技术联合中心生物能源联合研究组协调人，全国食品工业标准化技术委员会工业发酵分技术委员会委员，《Fermentation》杂志编委。

中国科学院特聘研究岗位入选者

中国科学院青年创新促进会会员

以主要完成人获国家海洋局海洋工程奖二等奖和国家海洋局海洋科学技术奖二等奖

已经开发了微生物蛋白、油脂和营养化学品等的细胞工厂10余个，相关技术建设了万吨级生产线。主持国家、省部级课题20余项，获得授权国家发明专利30余项，在Chemical Engineering Journal、Applied Catalysis B: Environment and Energy、Nature Communication、Biotechnology Advances、Journal of Agricultural and Food Chemistry、Sustainable Energy & Fuels、Reviews in Aquaculture等国际学术期刊共发表SCI论文100余篇。以主要完成人获国家海洋局海洋工程奖二等奖和国家海洋局海洋科学技术奖二等奖。

代表性论文（10篇）：

[1] Y. Zhou, Y. Duan, L. Chen, Y. Yang, L. Ma, W. Chen, Z. Liao, J. Cai, D. Li*, Engineering dispersed mycelium morphology in Aspergillus niger for enhanced mycoprotein production via CRISPR/Cas9-mediated genome editing, Bioresource Technology 432 (2025) 132652. https://doi.org/10.1016/j.biortech.2025.132652.

[2] Y. Zhai, L. Chen, L. Ma, Y. Duan, W. Chen, L. Long, G. Wang, A. Shi, G. Chen, D. Li*, Fluorescent protein-based anaerobic reporter for construction of promoter libraries in Clostridium autoethanogenum, International Journal of Biological Macromolecules 310 (2025) 143155. https://doi.org/10.1016/j.ijbiomac.2025.143155.

[3] Y. Hu, Y. Duan, Y. Zhang, L. Ma, Y. Zhai, W. Chen, L. Long, W. Bai, Y. Shen, L. Chen, X. Ren, D. Li*, Reprogramming Schizochytrium cell factory for High-Yield production of astaxanthin via mutagenesis and metabolic engineering, Chemical Engineering Journal 515 (2025) 163556. https://doi.org/10.1016/j.cej.2025.163556.

[4] Y. Duan, L. Chen, L. Ma, Y. Zhai, Y. Hu, G. Li, G. Chen, D. Li*, CRISPR/Cas9-mediated metabolic engineering for enhanced PUFA production in Schizochytrium limacinum, Chemical Engineering Journal 517 (2025) 164320. https://doi.org/10.1016/j.cej.2025.164320.

[5] S. Tong, R. Hong, W. Chen, M. Chai, Y. Zhang, Y. Sun, Q. Wang, D. Li*, Synchronous Bioproduction of Betanin and Mycoprotein in the Engineered Edible Fungus Fusarium venenatum, Journal of Agricultural and Food Chemistry 72 (2024) 19462-19469. 10.1021/acs.jafc.4c06071.

[6] S. Tong, W. Chen, R. Hong, M. Chai, Y. Sun, Q. Wang, D. Li*, Efficient Mycoprotein Production with Low CO2 Emissions through Metabolic Engineering and Fermentation Optimization of Fusarium venenatum, Journal of Agricultural and Food Chemistry 72 (2024) 604–612. 10.1021/acs.jafc.3c08509.

[7] R. Hong, S. Tong, M. Chai, W. Chen, X. Liu, Y. Chen, D. Li*, Enhancing Mycoprotein Yield: Metabolic Modulation of Chitin Synthase in Fusarium venenatum, Journal of Agricultural and Food Chemistry 72 (2024) 27274–27283. 10.1021/acs.jafc.4c07105.

[8] Y. Duan, L. Chen, L. Ma, F.R. Amin, Y. Zhai, G. Chen, D. Li*, From lignocellulosic biomass to single cell oil for sustainable biomanufacturing: Current advances and prospects, Biotechnology Advances 77 (2024) 108460. https://doi.org/10.1016/j.biotechadv.2024.108460.

[9] H. Cui, W. Liu, C. Ma, P. Shiri, Z. Zhu, H. Jiang, D. Li*, L. Zhang, Converting CO2 to single-cell protein via an integrated electrocatalytic-biosynthetic system, Applied Catalysis B: Environment and Energy 350 (2024) 123946. https://doi.org/10.1016/j.apcatb.2024.123946.

[10] J. Wang, L. Chen, J. Xu, S. Ma, X. Liang, Z. Wei, D. Li*, M. Xue, C1 gas protein: A potential protein substitute for advancing aquaculture sustainability, Reviews in Aquaculture 15 (2023) 1-19. https://doi.org/10.1111/raq.12707.

代表性专利（10项）：

1. 李德茂，段玉，马龙雪，陈利梅，陈吴西，李国华.重塑FAS途径的裂殖壶菌基因工程菌株、构建方法和应用.202510412628.0

2. 李德茂，李亚香，法鲁克·拉扎·阿民，段玉，一株高效转化餐厨垃圾生产单细胞蛋白的裂殖壶菌菌株及其应用. 202510703152.6

3. 李德茂，段玉，马龙雪，陈利梅，陈吴西，胡意. 高效生产DHA的裂殖壶菌基因工程菌株、构建方法和应用. 202510412589.4

4. 李德茂，段玉，马龙雪，陈利梅，陈吴西.内源tRNA启动子及破囊壶菌科微生物基因编辑方法. 202411864456.2

5. 李德茂，翟艺达，陈利梅，哈立德·哈比巴. 启动子文库、用于产醇梭菌的荧光报告系统及应用.2024105001201

6. 李德茂，洪如如，王钦宏，童胜，陈吴西，马龙雪，柴梦丹. 几丁质合成酶Fvchs3及其在提高威尼斯镰刀菌菌丝蛋白产量中的应用.202411037070.4

7. 李德茂，童胜，王钦宏，洪如如，陈吴西. 同时提高镰刀菌菌丝体蛋白和甜菜红素产量的方法.2024105145833

8. 马延和，童胜，李德茂，安可心，陈吴西，王钦宏，孙媛霞. 威尼斯镰刀菌TB01的整合位点及其应用.2022113845123

9. 马延和，童胜，李德茂，王钦宏，陈吴西，孙媛霞.      威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法. 2022103145064

10. 马延和，李德茂，齐显尼，曾艳，王钦宏，孙媛霞.一株产蛋白的菌株及其应用. 202011415776.1