李志超----中国科学院天津工业生物技术研究所

人才队伍

研究员/正高级工程师

李志超

职　　称：研究员
学　　历：博士研究生
导师类别：博士生导师
通讯地址：天津市空港经济区西七道32号
电　　话：022-24828727
邮政编码：300308
电子邮件：Lizhch@tib.cas.cn
部　　门：基因组转移与生物底盘工程研究组

简历

2008年-2014年，中国科学院植物所，博士

2014年-2019年，德国马普分子植物生理研究所，博士后

2019年至今，中国科学院天津工业生物技术研究所，研究员，博士生导师

研究方向

工作定位于应用基础研究，以生物合成底盘及底层分子使能技术为研究开发对象，服务于合成生物学。主要以高等植物、藻类、模式底盘微生物等为研究材料，开发多种基因组（细胞核、叶绿体、线粒体）转化、编辑、转移融合等基因工程技术并以此构建新型的生物合成底盘。具体从事解析水平基因转移（天然转基因）进化事件的分子机制，借此开发全新高效的基因递送及表达调控、基因组转移、融合、扩增等基因工程及合成生物学使能技术；并以此构建包括植物悬浮细胞、创新微生物等新型的生物合成底盘和细胞工厂，对传统微生物底盘合成困难的高值产品（如植物天然产物）进行高效生物合成。

获奖及荣誉

中国科学院人才引进计划择优支持

代表成果

1. Sun YW, Bock R, Li ZC* (2025) A hidden intrinsic ability of bicistronic expression based on a novel translation reinitiation mechanism in yeast (封面文章), Nucleic Acids Research (IF: 16.6), 53, 6. (*：通讯作者)

2. Yuan W, Yu J, Li ZC* (2024) Rapid functional activation of horizontally transferred eukaryotic intron-containing genes in the bacterial recipient, Nucleic Acids Research (IF: 16.6), 52, 14, 8344-8355.

3. Zhang FQ, Shi XX, Xu J, Yuan W, Li ZC* (2024) Tandem gene duplication selected by activation of horizontally transferred gene in bacteria, Applied Microbiology and Biotechnology, 108(1).

4. Yu J; Wang X; Yuan Q; Shi J; Cai J; Li ZC*, Ma H* (2023) Elucidating the impact of in vitro cultivation on Nicotiana tabacum metabolism through combined in silico modeling and multiomics analysis. Frontiers in plant science, 14:1281348.

5. Zhu XX, Liu XN, Liu T, Wang Y, Ahmed N, Li ZC*, Jiang HF* (2021) Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells. Plant Communications (IF: 9.4), 2, 100229.

6. Li ZC, Bock R* (2019) Rapid functional activation of a horizontally transferred eukaryotic gene in a bacterial genome in the absence of selection. Nucleic Acids Research (IF: 16.6) doi: 10.1093/nar/gkz370.

7. Li ZC, Bock R* (2018) Replication of bacterial plasmids in the nucleus of the red alga Porphyridium purpureum. Nature Communications (IF: 14.7) 9, 3451.

8. Li ZC, He CY*. (2015) Physalis floridana Cell Number Regulator1 encodes a cell membrane-anchored modulator of cell cycle and negatively controls fruit size. Journal of Experimental Botany 66, 257–270.

9. Zhang JS#, Li ZC#, Zhao J, Zhang SH, Quan H, Zhao M, He CY* (2014) Deciphering the Physalis floridana Double-Layered-Lantern1 mutant provides insights into functional divergence of theGLOBOSAduplicates within the Solanaceae. Plant Physiology (IF: 8.1), 164, 748–764. (#：共同一作)

10. Wang L, He LL, Li J, Zhao J, Li ZC, He CY* (2014) Regulatory change at Physalis Organ Size 1 locus correlates to natural variation in tomatillo reproductive organ size. Nature Communications 5, 4271.

11. Wang L, Li ZC, He CY* (2012) Transcriptome-wide mining of the differently expressed transcripts for natural variation of floral organ size in Physalis philadelphica. Journal of Experimental Botany 63, 6457–6465.