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姓名  
苏浩
性别  
专家类别  
N/A
职称  
副研究员
学历  
博士研究生
电话  
022-24828738
传真  
N/A
电子邮件  
suhao(AT)tib.cas.cn(请将AT替换为@)
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2021.10-至今  中国科学院天津工业生物技术研究所  副研究员

2019.04-2021.06  瑞典皇家理工学院  博士后

2017.07-2019.04  耶路撒冷希伯莱大学  博士后

2012.09-2017.06  山东大学  博士

2008.09-2012.07  山西大同大学  学士


研究方向:
  

利用多尺度计算化学方法解析酶的底物结合模式、结构-功能关系,开发酶理性设计改造新策略。具体研究内容包括:酶催化机制解析;酶的理性设计与改造。

    

代表论著

完整论文列表见:Hao Su (0000-0002-0178-6610) (orcid.org)

1. Hao Su, Marten S. G. Ahlquist*

Nonbonded Zr4+ and Hf4+ Models for Simulations of Condensed Phase Metal–Organic Frameworks. J. Phys. Chem. C, 2021, 125, 11, 6471–6478.

2. Hao Su, Binju Wang* and Sason Shaik*

   Quantum-Mechanical/Molecular-Mechanical Studies of CYP11A1-Catalyzed Biosynthesis of Pregnenolone from Cholesterol Reveal a C–C Bond Cleavage Reaction That Occurs by a Compound I-Mediated Electron Transfer

   J. Am. Chem. Soc., 2019, 141, 51, 20079–20088.

3. Hao Su, Guangcai Ma and Yongjun Liu*

Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes

Inorg. Chem., 2018, 57, 11738-11745.

4. Hao Su, Guangcai Ma and Yongjun Liu*

Quantum Mechanics/Molecular Mechanics Study on the Catalytic Mechanism of Non-Heme Dioxygenase AsqJ

ACS Catal., 2017, 7, 5534–5543.

5. Hao Su, Xiang Sheng and Yongjun Liu*

Exploring the Substrate Specificity and Catalytic Mechanism of Imidazolonepropionase (HutI) from Bacillus subtilis.

Phys. Chem. Chem. Phys., 2016,18, 27928-27938.

6. Hao Su, Xiang Sheng and Yongjun Liu*

Insights into the Catalytic Mechanism of N-acetylglucosaminidase Glycoside Hydrolase from Bacillus subtilis: a QM/MM study.

Org. Biomol. Chem., 2016, 14, 3432–3442.

7. Hao Su, Lihua Dong and Yongjun Liu*

A QM/MM study of the catalytic mechanism of α-1, 4-glucan lyase from the red seaweed Gracilariopsis lemaneiformis.

RSC Adv., 2014, 4, 54398-54408.

8. Haibo Wu, Hao Su, Erik Schulze, et al. M?rten S. G. Ahlquist and Pher G. Andersson*

Site- and Enantioselective Iridium-Catalyzed Desymmetric Mono-Hydrogenation of 1,4-Dienes.

Angew. Chem. Int. Ed. 2021, 60,19428–19434.

9. Jianping Yang, Luca Massaro, Suppachai Krajangsri, Thishana Singh, Hao Su, Emanuele Silvi, Sudipta Ponra, Lars Eriksson, Marten S. G. Ahlquist, and Pher G. Andersson* Combined Theoretical and Experimental Studies Unravel Multiple Pathways to Convergent Asymmetric Hydrogenation of Enamides.

    J. Am. Chem. Soc. 2021, 143, 21594-21603.


承担科研项目情况:
  

获奖及荣誉: