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  副研究员
 
姓名  
袁倩倩
性别  
专家类别  
N/A
职称  
副研究员
学历  
博士研究生
电话  
022-24828756
传真  
022-24828756
电子邮件  
yuan_qq@tib.cas.cn
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

1. 教育经历

2006.09-2011.06,哈尔滨医科大学,生物信息学,学士学位

20011.09-2013.06,天津大学,生物化工,硕士学位

2013.07-2017.06,天津大学,生物化工,博士学位

2. 工作经历

2017.07-2020.04,中国科学院天津工业生物技术研究所,博士后

2020.04-至今,中国科学院天津工业生物技术研究所,生物设计中心,副研究员


研究方向:
  

长期从事计算系统生物学指导的高效生物转化途径的系统设计和构建研究,致力于代谢网络模型构建、模型质控方法开发、非天然途径设计算法开发、代谢工程改造靶点预测等方向研究。重点开展了模型理性指导下的碳一途径设计研究,开发了途径设计算法comb-FBA,近两年来重点开展模型质控、途径设计在线工具的开发,致力为实验生物学家提供易用可靠的工具。


承担科研项目情况:
  

主持科技部国家重点研发计划子课题2项、国家自然科学基金青年基金项目1项、天津市人才基金项目1项。


获奖及荣誉:
  

2022年入选中国科学院青年促进会会员

2023年入选中国科学院第四届“科苑名匠(团队)”:工程菌种铸造科学设施团队


代表论著:

在国内外期刊发表文章 40余篇,引用1070次,h指数14。第一或通讯作者发表SCI研究性论文 10篇;申请发明专利 3项,授权专利 3项;登记软件著作权3项。

代表性论文:

[1] Mao Zhitao#, Yuan Qianqian #, Li Haoran #, Zhang Yue, Huang Yuanyuan, Yang Chunhe, Wang Ruoyu, Yang Yongfu, Wu Yalun, Yang Shihui, Liao Xiaoping*, Ma Hongwu*. CAVE: a cloud-based platform for analysis and visualization of metabolic pathways. Nucleic Acids Research, 2023, gkad360.

[2] Yuan Qianqian#, Wei Fan #, Deng Xiaogui, Li Aonan, Shi Zhenkun, Mao Zhitao, Li Feiran*, Ma Hongwu*. Reconstruction and metabolic profiling of the genome-scale metabolic network model of Pseudomonas stutzeri A1501. Synthetic and Systems Biotechnology, 2023.

[3] Luo Jiahao; Yuan Qianqian#; Mao Yufeng; Wei fan; Zhao Juntao; Yu Wentong; Kong Shutian; Guo Yanmei; Cai Jingyi; Liao Xiaoping; Wang Zhiwen*, Hongwu Ma*. Reconstruction of a Genome-Scale Metabolic Network for Shewanella oneidensis MR-1 and Analysis of its Metabolic Potential for Bioelectrochemical Systems. Frontiers in bioengineering and biotechnology, 2022, 10: 913077-913077.

[4] Mao Yufeng#; Yuan Qianqian#; Yang Xue; Liu Pi; Cheng Ying; Luo Jiahao; Liu Huanhuan; Yao Yonghong; Sun Hongbing; Cai Tao; Ma Hongwu*; Non-natural Aldol Reactions Enable the Design and Construction of Novel One-Carbon Assimilation Pathways in vitro, Frontiers in Microbiology, 2021, 12(1360): 677596.

[5] Yuan, Xiao-Jie#; Chen, Wen-Jing#; Ma, Zeng-Xin#; Yuan, Qian-Qian#; Zhang, Min; He, Lian; Mo, Xu-Hua; Zhang, Chong; Zhang, Chang-Tai; Wang, Meng-Ying; Xing, Xin-Hui; Yang, Song*; Rewiring the native methanol assimilation metabolism by incorporating the heterologous ribulose monophosphate cycle into Methylorubrum extorquens, Metabolic Engineering, 2021, 64: 95-110.

[6] Cai, Tao; Sun, Hongbing; Qiao, Jing; Zhu, Leilei; Zhang, Fan; Zhang, Jie; Tang, Zijing; Wei, Xinlei; Yang, Jiangang; Yuan, Qianqian; Wang, Wangyin; Yang, Xue; Chu, Huanyu; Wang, Qian; You, Chun; Ma, Hongwu; Sun, Yuanxia; Li, Yin; Li, Can; Jiang, Huifeng; Wang, Qinhong; Ma, Yanhe*; Cell-free chemoenzymatic starch synthesis from carbon dioxide, Science, 2021, 373(6562): 1523.

[7] Wen, Mao#; Yuan, Qian-Qian #; Hongge, Qi; Zhiwen, Wang; Hongwu, Ma; Tao, Chen*; Recent progress in metabolic engineering of microbial formate assimilation, Applied Microbiology and Biotechnology, 2020, 104(16): 6905-6917.

[8] Yang, Xue#; Yuan, Qian-Qian #; Luo, Hao; Li, Feiran; Mao, Yufeng; Zhao, Xin; Du, Jiawei; Li,vPeishun; Ju, Xiaozhi; Zheng, Yangyang; Chen, Yang; Liu, Yuwan; Jiang, Huifeng; Yao, Yonghong; Ma, Hongwu*; Ma, Yanhe ; Systematic design and in vitro validation of novel one-carbon assimilation pathways, Metabolic Engineering, 2019, 56: 142-153.

[9] Yuan, Qian-Qian; Huang, Teng; Li, Peishun; Hao, Tong; Li, Feiran; Ma, Hongwu*; Wang, Zhiwen*; Zhao, Xueming; Chen, Tao*; Goryanin, Igor; Pathway-Consensus Approach to Metabolic Network Reconstruction for Pseudomonas putida KT2440 by Systematic Comparison of Published Models. PLos One, 2017, 12(1): e0169437.