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  研究员
 
姓名  
毕昌昊
性别  
专家类别  
N/A
职称  
研究员
学历  
博士
电话  
N/A
传真  
N/A
电子邮件  
bi_ch@tib.cas.cn
地址  
天津空港经济区西七道32号
邮编  
300308

简历

教育经历:

2009 佛罗里达大学, Gainesville, FL,美国,理学博士,微生物与细胞生物学

2004 南开大学, 天津,科学硕士,生物化学与分子生物学

2001 南开大学, 天津,科学学士,生物化学

工作经历:

2011至2013,The Joint BioEnergy Institute (JBEI), 美国劳伦斯伯克利国家实验室, 研究生物学家

2009至2011,特拉华大学, 化工系,博士后研究员

2004至2009,佛罗里达大学,微生物与细胞生物学系, Gainesville,博士研究生,实验助理,教学助理


研究方向:
  

合成生物技术小组的目标是通过开发使能技术来推动合成生物研究和应用的极限。我们专注于DNA和基因组操作技术,以更快、更深、更大的方式控制DNA。主要研究领域是合成生物学技术,重点发展和应用新的方法和技术,如基因组和碱基编辑技术、体内DNA进化和突变技术以及人工微生物细胞器和人工生命形式的构建。

 

代表论著:

1.  Wang, W., He, P., Zhao, D., Ye, L., Dai, L., Zhang, X*., Bi, C*. (2019). Construction of Escherichia coli cell factories for crocin biosynthesis. Microbial cell factories, 18(1), 120. 二区

2.  Wu, T., Li, S, Zhang, X*,Bi, C*. (2019). Engineering an Artificial Membrane Vesicle Trafficking System (AMVTS) for the Excretion of β-Carotene in Escherichia coli. ACS Synth. Biol 二区

3.  Wu, Z., Wang, J., Zhang, Zhang, X*,Bi, C*. (2019). Engineering an electroactive Escherichia coli for the microbial electrosynthesis of succinate by increasing the intracellular FAD pool. Biochemical Engineering Journal. 146(132-142) 二区

4.  Wu, Z., Wang, J., Liu, J., Wang, Y., Bi, C*., Zhang, X*. (2019). Engineering an electroactive Escherichia coli for the microbial electrosynthesis of succinate from glucose and CO 2. Microbial cell factories18(1), 15. 二区

5.      Li, Z., Xiong, B., Liu, L., Li, S., Xin, X., Li, Z., Zhang, X*, Bi, C*. (2019). Development of an autotrophic fermentation technique for the production of fatty acids using an engineered Ralstonia eutropha cell factory. Journal of industrial microbiology & biotechnology, 1-8. 二区

6.      Ye, L., Zhu, X., Wu, T., Wang, W., Zhao, D., Bi, C. *.,  Zhang, X*. (2018). Optimizing the localization of astaxanthin enzymes for improved productivity. Biotechnology for biofuels, 11(1), 278. 一区

7.      Xiong, B., Li, Z., Liu, L., Zhao, D., Zhang, X*., Bi, C*. (2018). Genome editing of Ralstonia eutropha using an electroporation-based CRISPR-Cas9 technique. Biotechnology for Biofuels11(1), 172. 一区

8.      Wu, T., Li, S., Zhang, B., Bi C*, Zhang X*. (2018). Engineering Saccharomyces cerevisiae for the production of the valuable monoterpene ester geranyl acetate. Microbial cell factories17(1), 85. 二区

9.      Wu, T., Ye, L., Zhao, D., Li, S., Li, Q., Zhang, B*., Bi, C*. (2018). Engineering membrane morphology and manipulating synthesis for increased lycopene accumulation in Escherichia coli cell factories. 3 Biotech8(6), 269. 三区

10.    Feng, X., Zhao, D., Zhang, X., Ding, X*., & Bi, C*. (2018). CRISPR/Cas9 assisted Multiplex Genome Editing Technique in Escherichia coli. Biotechnology journal, 1700604. 二区

11.    Zhao, D., Feng, X., Zhu, X., Wu, T., Zhang, X*., and Bi, C*. (2017) CRISPR/Cas9-assisted gRNA-free one-step genome editing with no sequence limitations and improved targeting efficiency, Scientific Reports. 2017. 16624. 三区 

12.    Zhu X, Zhao D, Qiu H, Fan F, Man S, Bi C*, Zhang X*(2017). The CRISPR/Cas9-facilitated multiplex pathway optimization (CFPO) technique and its application to improve the Escherichia coli xylose utilization pathway. Metab Eng. 43:37-45. 一区 

13.    Wu T, Ye L, Zhao D, Li S, Li Q, Bi C*, Zhang X*. (2017) Membrane engineering - A novel strategy to enhance the production and accumulation of β-carotene in Escherichia coli. Metab Eng., 43: 85-91. 一区 

14.    Li Q, Fan F, Gao X, Yang C, Bi C, Tang J, Liu T, Zhang X*. (2017) Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli. Metab Eng.08.005 一区 

15.    Ye L, He P, Li Q, Zhang X*, Bi C*. (2017) Type IIs restriction based combinatory modulation technique for metabolic pathway optimization. Microb Cell Fact. 16:47. 二区 

16.    Xiao M, Zhu X, Xu H, Tang J, Liu R, Bi C, Fan F*, Zhang X*. (2017) A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli. BMC Biotechnology. 17:10 二区 

17.    Li J, Zhu, X Chen, J Zhao, D., Zhang X*, Bi, C*. (2017) Construction of a novel anaerobic pathway in Escherichia coli for propionate production. BMC biotechnology17(1), 38. 二区 

18.    Zhao D, Yuan S, Xiong B, Sun H, Ye L, Li J, Zhang X*, Bi C*. (2016) Development of a fast and easy method for Escherichia coli genome editing with CRISPR/Cas9 Microb Cell Fact. 15:205. 二区 

19.    Ye L, Zhang C, Bi C, Li Q*, Zhang X*. (2016) Combinatory Optimization of Chromosomal Integrated Mevalonate Pathway for β-carotene Production in Escherichia coli. Microb Cell Fact. 2016, 15:202.6 二区 

20.    Li S, Ding W, Zhang X, Jiang H*, Bi C*. (2016) Development of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae. Biotechnol Biofuels. 2016, 9:232 一区 

21.    Sun H, Zhao D, Xiong B, Zhang C*, Bi C*. (2016). Engineering Corynebacterium glutamicum for violacein hyper production. Microb Cell Fact.15(1), 148. 二区


承担科研项目情况:
  
主持(首席科学家)863计划项目“生物质的快速气化与生物转化关键技术”  。 

获奖及荣誉: