1994.9-1998.6,   南开大学, 微生物学专业, 学士学位

1999.9-2002.6,   南开大学, 生物化学和分子生物学专业，硕士学位 

2002.9-2006.1,   中国科学院微生物研究所, 微生物学专业，博士学位

2006.3-2010.6，  美国西奈山医学院，博士后

2010.7-2013.12,  美国西奈山医学院, 研究助理教授

2014.2-目前，    中国科学院天津工业生物技术研究所，研究员

围绕谷氨酸棒杆菌等重要工业微生物的生理和代谢开展以下研究:

1. 解析重要工业微生物对环境胁迫的生理机制，在此基础上构建具有抗逆性能的工业菌种。

2. 阐明重要工业微生物合成特定代谢产物的分子基础和调控机制，并利用合成生物学和代谢工程等技术实现工业菌种的遗传改造。

1. Du H, Qi Y, Qiao J, Li L, Wei L, Xu N, Shao L, Liu J*. 2023. Transcription factor OxyR regulates sulfane sulfur removal and L-cysteine biosynthesis in Corynebacterium glutamicum. Appl Environ Microbiol., 89(9):e0090423.

2. Du H, Qi Y, Qiao J, Li L, Xu N, Shao L, Wei L*, Liu J*. 2023. Balancing Redox Homeostasis to Improve l-Cysteine Production in Corynebacterium glutamicum. J Agric Food Chem., 71(37):13848-13856.

3. Du H, Qiao J, Qi Y, Li L, Xu N, Shao L, Wei L*, Liu J*. 2023. Reprogramming the sulfur recycling network to improve l-cysteine production in Corynebacterium glutamicum. Green Chem., 25, 3152-3165.

4. Ju Y^#, Zhang H^#, Du X, Wei J, Liu J, Wei L*, Liu Q*, Xu N*. 2023. DRAGON: Harnessing the power of DNA repair for accelerating genome evolution in Corynebacterium glutamicum. Metab Eng., 79:182-191.

5. Wang T, Zhang J, Wei L, Zhao D, Bi C, Liu Q, Xu N*, Liu J*. 2023. Developing a PAM-Flexible CRISPR-Mediated Dual-Deaminase Base Editor to Regulate Extracellular Electron Transport in Shewanella oneidensis. ACS Synth Biol., 12(6):1727-1738.

6. Gao J, Du M, Zhao J, Yue Zhang, Xu N, Du H, Ju J, Wei L*, Liu J*. 2022. Design of a genetically encoded biosensor to establish a high-throughput screening platform for L-cysteine overproduction. Metab Eng., 73:144-157.

7. Wei L, Zhao J, Wang Y, Gao J, Du M, Zhang Y, Xu N, Du H, Ju J, Liu Q*, Liu J*. 2022. Engineering of Corynebacterium glutamicum for high-level γ-aminobutyric acid production from glycerol by dynamic metabolic control. Metab Eng., 69:134-146.

8. Xu N, Liu Y, Jiang H*, Liu J*, Ma Y. 2020. Combining protein and metabolic engineering to construct efficient microbial cell factories. Curr Opin Biotechnol., 2020. 66:27-35.

9. Wei L, Wang Q, Xu N, Cheng J, Zhou W, Han GQ, Jiang HF*, Liu J*, Ma YH.2019. High-level o-acetylhomoserine production in Escherichia coli through protein and metabolic engineering. ACS Synth Biol., 8(5):1153-1167.

10. Xu N, Zheng YY, Wang XC, Krulwich TA, Ma YH, Liu J*. 2018. The lysine 299 residue endows the multisubunit Mrp1 antiporter with dominant roles in Na⁺-resistance and pH homeostasis in Corynebacterium glutamicum. Appl Environ Microbiol., 84: e00110-18.