主要从事工业微生物的基因编辑育种和碳一原料的生物转化研究，致力于开发适用于谷氨酸棒杆菌等工业微生物的先进基因编辑与调控技术，采用系统与合成生物技术方法拓展工业微生物的底物谱和产物谱，实现生物转化甲醇等碳一原料和甘油等非粮原料合成大宗和精细化学品。

以第一或通讯作者在Nat. Commun.、Trends Biotechnol.、Metab. Eng.、ACS Synth. Biol.等期刊发表论文30余篇，申请专利30余项；入选国家级人才计划、中科院特聘研究员、中科院青年创新促进会、《麻省理工科技评论》亚太区“35岁以下科技创新35人”、“伦世仪教育基金”杰出青年学者等，曾获日本生物工学会DaSilva Award和明治生命科学奖等荣誉。

Website:

https://orcid.org/0000-0002-0957-9245

 

代表论著：

1.        Liu J, Liu M, Shi T, Sun G, Gao N, Zhao X, Guo X, Ni X, Yuan Q, Feng J, Liu Z, Guo Y, Chen J, Wang Y*, Zheng P*, Sun J. 2022. CRISPR-assisted rational flux-tuning and arrayed CRISPRi screening of an L-proline exporter for L-proline hyperproduction. Nat Commun, 13, 891 (Editors’ highlights and Focus article on biotechnology and method).

2.        Wang Y, Zhao D, Sun L, Wang J, Fan L, Cheng G, Zhang Z, Ni X, Feng J, Wang M, Zheng P*, Bi C*, Zhang X*, Sun J. 2022. Engineering of the translesion DNA synthesis pathway enables controllable C-to-G and C-to-A base editing in Corynebacterium glutamicum. ACS Synth Biol, 11, 3368–3378.

3.        Chen J, Wang Y*, Zheng P*, Sun J. 2022. Engineering synthetic auxotrophs for growth-coupled directed protein evolution. Trends Biotechnol, 40, 773–776.

4.        Wang Y*, Zheng P, Sun J*. 2022. Developing synthetic methylotrophs by metabolic engineering-guided adaptive laboratory evolution. Adv Biochem Eng Biotechnol, 180, 127–148.

5.        Zhou W, Fu G, Qi X, Zheng X, Fang H, Xia M, Zhang D, Wang Q, Zheng P, Wang Y*, Sun J. 2022. Upgrading microbial strains for fermentation industry. Chin J Biotech, 38, 1–19.

6.        Wang Y*, Cheng H, Liu Y, Liu Y, Wen X, Zhang K, Ni X, Gao N, Fan L, Zhang Z, Liu J, Chen J, Wang L, Guo Y, Zheng P*, Wang M*, Sun J, Ma Y. 2021. In-situ generation of large numbers of genetic combinations for metabolic reprogramming via CRISPR-guided base editing. Nat Commun, 12, 678 (Editors’ highlights and Focus article on biotechnology and method).

7.        Wang Y*, Liu Y, Zheng P, Sun J, Wang M*. 2021. Microbial base editing: a powerful emerging technology for microbial genome engineering. Trends Biotechnol, 39, 165–180 (Selected cover and free featured article).

8.        Zhang Z, Wang Y*, Zheng P*, Sun J. 2021. Promoting lignin valorization by coping with toxic C1 byproducts. Trends Biotechnol, 39, 331–335.

9.        Wang Y, Fan L, Tuyishime P, Liu J, Zhang K, Gao N, Zhang Z, Ni X, Feng J, Yuan Q, Ma H, Zheng P*, Sun J*, Ma Y. 2020. Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum. Commun Biol, 3:217 (Springer Nature high impact publications by Chinese researchers).

10.      Wang Y, Fan L, Tuyishime P, Zheng P*, Sun J*. 2020. Synthetic methylotrophy: a practical solution for methanol-based biomanufacturing. Trends Biotechnol, 38, 650–666.

11.      Wang Y, Liu Y, Li J, Yang Y, Ni X, Cheng H, Huang T, Guo Y, Ma H, Zheng P*, Wang M*, Sun J, Ma Y. 2019. Expanding targeting scope, editing window, and base transition capability of base editing in Corynebacterium glutamicum. Biotechnol Bioeng, 116:3016–3029 (Selected cover article).

12.      Wang Y, Liu Y, Liu J, Guo Y, Fan L, Ni X, Zheng X, Wang M*, Zheng P*, Sun J*, Ma Y. 2018. MACBETH: multiplex automated Corynebacterium glutamicum base editing method. Metab Eng, 47:200–210.

13.      Wang Y, Cao G, Xu D, Fan L, Wu X, Ni X, Zhao S, Zheng P*, Sun J*, Ma Y. 2018. A novel Corynebacterium glutamicum L-glutamate exporter. Appl Environ Microbiol, 84:e02691-17.

14.      Tuyishime P^#, Wang Y^#, Fan L, Zhang Q, Li Q, Zheng P*, Sun J*, Ma Y. 2018. Engineering Corynebacterium glutamicum for methanol-dependent growth and glutamate production. Metab Eng, 49:220–231.

15.      Wang Y, Tao F, Xin B, Liu H, Gao Y, Zhou NY, Xu P*. 2017. Switch of metabolic status: redirecting metabolic flux for acetoin production from glycerol by activating a silent glycerol catabolism pathway. Metab Eng, 39:90–101.