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  研究员
 
姓名  
赵磊
性别  
专家类别  
N/A
职称  
研究员
学历  
博士研究生
电话  
022-24828786
传真  
N/A
电子邮件  
zhaol(AT)tib.cas.cn(请将AT替换为@)
地址  
天津市空港经济区西七道32号
邮编  
300308

简历

2008.09 - 2014.07,中国科学院植物研究所,博士

2014.07 - 2016.09,中国科学院植物研究所,助理研究员

2016.10 - 2019.10,马萨诸塞大学细胞生物学系,博士后

2019.11 - 2020.09,中国农业科学院作物科学研究所,研究员

2020.10 - 至今,  中国科学院天津工业生物技术研究所,研究员


研究方向:
  

主要致力于低碳合成生物系统的人工设计与创建等研究工作。研究内容包括重要功能元件的发掘、设计与模块组装,并综合运用遗传学、细胞生物学、合成生物学等原理和方法,进行重要植物底盘细胞的人工设计改造及应用,以实现高附加值化学品、重组蛋白、天然产物等的绿色生物制造。 

 

代表论著

30. Wang Q, Zhang JF, Yang H, Dai QL, Cui MJ, Cao PJ#, Zhao L# (2023) When Green Carbon Plants Meet Synthetic Biology. Modern Agriculture, Under review

29. Zhao LQ*, Ge TL*, Cheng TF, Wang Q, Cui MJ, Yuan HL, Zhao L# (2023) Fine-tuning gene expression of the transcriptional regulator AdmX for improved biosynthesis of andrimid in Erwinia persicina strain BST187. Applied Microbiology Biotechnology, Major revision 

28. Hou YY*, Han T*, Wu RR, Liu ZY, Ma YB, Guo ZL, Hao NH, Wang WJ, Ji X, Zhu ZG, Chen FJ#, Zhao L# (2023) A Novel System Integrating Electrolysis and Ionic Membranes (EIMs) Enabling the Artifical Carbon Concentration and Alleviation of Metal Cation Stress in Microalgae Cultivation. Green Chemistry, DOI:10.1039/d3gc01656k

27. Liu ZY*, Hao NH*, Hou YY, Wang Q, Liu QL, Yan SH, Chen FJ, Zhao L# (2023) Technologies for the harvesting of microalgae for industrial applications: Current Trends and Perspective. Bioresource Technology, 387: 129631

26. Cheng TF, Ge TL, Zhao LQ, Hou YY, Xia JY#, Zhao L# (2023) Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization. BMC Microbiology, DOI: 10.1186/s12866-023-02946-2

25. Wang Q, He H, Xiong W, Cao PJ, Cheng J#, Zhao L# (2023) Editorial: Synthetic Metabolism for the Third-Generation (3G) Biorefineries. Frontiers in Bioengineering Biotechnology, 11: 1214729

24. Ma YB*, Hou YY*, Wang WJ, Cui MJ, Guo ZL, Han T, Liu ZY, Hao NH, Chen FJ, Zhao L# (2023) Insights into Carbon Utilization Under Mixotrophic Conditions in Chlamydomonas. Bioresource Technology, 374: 128788

23. Hao NH*, Liu ZY*, Hou YY, Fan ZH, Li Y, Chen FJ# , Zhao L (2022) Small peptide glutathione-induced bioflocculation for enhancing the food application potential of Chlorella pyrenoidosa. Bioresource Technology, 365: 128138

22. Guo ZL*, Hou YY*, Liu ZY, Ma YB, Han T, Hao NH, Yao YJ, Lan CX, Ge TL, Wang WJ#, Zhao L#, Chen FJ# (2022) Combination of bicarbonate and low temperature stress induces the biosynthesis of both arachidonic and docosahexaenoic acids in alkali-halophilic microalgae. Frontiers in Marine Science, 9: 971441

21. Wang Q, Yang H, Cao PJ, Chen FJ, Zhao L# (2022) Biosynthetic approaches to efficient assimilation of CO2 by reducing carbon release via photorespiration modification in plant chassis. Frontiers in Bioengineering Biotechnology, 10: 979627

20. Wu D*, Hou YY*, Cheng J, HanT, Hao NH, Zhang BJ, Fan X, Ji X#, Chen FJ#, Gong DH, Wang L, Patrick M, Zhao L#, Chen SL (2022) Transcriptome analysis of lipid metabolism in response to cerium stress in the oleaginous microalga Nannochloropsis oculata. Science of Total Environment, 838 (Pt3): 156420

19. Hou YY*, Liu CC*, Liu ZY, Han T, Hao NH, Guo ZL, Wang WJ, Chen SL, Zhao L#, Safavi M, Ji X#, Chen FJ# (2022) A Novel Salt-bridge Electroflocculation Technology for Harvesting Microalgae. Frontiers in Bioengineering Biotechnology, 10: 902524

18. Shi ML, Zhou L, Wang Qing, Zhao L# (2022) Advances in the study on the modification of carbon dioxide metabolic pathways by synthetic biology in plant. Synthetic Biology Journal (Chinese), 3: 1-20

17. Shi ML, Ge TL, Wang Y#, Zhao L# (2022) Photorespiration is essential for acclimation to salt stress under high carbon availability in Chlamydomonas. Algal Research, 64, 102687 

16. Shi ML, Zhou L, Cui MJ, Ge TL, Chen FJ, Zhao L# (2022) Roles of Light-Harvesting Complex Stress-Related Proteins in the Stress Responses of Chlamydomonas. Journal of Plant Sciences, 10 (1): 1-11

15. Zhou L, Liang XM, Zhao L# (2022) Biosynthesis of natural carotenoids: Progress and Perspective. Biotechnology Bulletin (Chinese), 38 (7): 61-69

14. Kai Cai, Zhao YH*, Zhao L*, Hou YQ, Cheng X, Daniela N, Witman G# (2021) Structural organization of the C1b projection within the ciliary central apparatus. The Journal of Cell Science, jcs.254227

13. Zhang L, Qi YZ, Wu MM, Zhao L, Zhao ZC, Lei CL, Hao YY, Yu XW, Sun YL, Zhang X, Guo XP, Ren YL, Wan JM# (2021) Mitochondrion-targeted PENTATRICOPEPTIDE REPEAT5 is required for cis-splicing of nad4 intron 3 and endosperm development in rice. The Crop Journal, 9: 282-296

12. Shi ML, Zhao L#, Wang Y# (2021) Identification and characterization of the genes encoding hydroxypyruvate reductase in Chlamydomonas. Frontiers in Plant Science, 12:690296 

11. Cai MH*, Zhu SS*, Wu MM*, Zheng XM, Wang JC, Zhou L, Zheng TH, Cui S, Zhou SR, Li CN, Zhang H, Chai JT, Zhang XY, Jin X, Cheng ZJ, Zhang X, Lei CL, Ren YL, Lin QB, Guo XP, Zhao L, Wang J, Zhao ZC, Jiang L, Wang HY, Wan JM# (2021) DHD4, a CONSTANS-like family transcription factor, delays heading date by affecting the formation of the FAC complex in rice. Molecular Plant,14 (2):330-343  (IF=27.45)

10. Hou YQ*, Zhao L*, Kubo T, Cheng X, McNeill N, Oda T, Witman G# (2021) Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a. The Journal of Cell Science, 134 (12): jcs258540

9. Yu MZ, Wu MM, Ren YL, Wang YH, Li JF, Lei CL, Sun YL, Bao XH, Wu HM, Yang H, Pan T, Wang YF, Jing RN, Yan MY, Zhang HD, Zhao L, Zhao ZC, Zhang X, Guo XP, Cheng ZJ, Yang B, Jiang L, Wan JM# (2021) Rice FLOURY ENDOSPERM 18 encodes a pentatricopeptide repeat protein required for 5' processing of mitochondrial nad5 messenger RNA and endosperm development. Journal of Integrative Plant Biology, 63:834-847

8. Zhao L, Hou YQ, McNeill N, Witman G# (2020) The unity and diversity of the ciliary central apparatus. Philosophical Transactions B., 375(1792):20190164

7. Zhao L, Hou YQ, Picariello T, Craige B, Witman G# (2019) Proteome of the central apparatus of a ciliary axoneme. The Journal of Cell Biology 218 (6) 2051-2070

6. Fu G*, Zhao L*, Dymek E, Hou YQ, Song KK, Phan N, Shang ZG, Smith EF, Witman G, Nicastro Daniela# (2019) Structural organization of the C1a-e-c supercomplex within the ciliary central apparatus. The Journal of Cell Biology, 218 (12) 4236-4251

5. Xing JL, Liu P, Zhao L, Huang F# (2017) Deletion of CGLD1 Impairs PSII and Increases Singlet Oxygen Tolerance of Green Alga Chlamydomonas reinhardtii. Frontiers in Plant Science, 8: 2154

4. Zhao L, Cheng DM, Huang XH, Chen M, Dall’Osto L, Xing JL, Gao LY, Li LY, Wang YL, Bassi R, Peng LW, Wang YC, Rochaix JD, Peng LW, Wang YC, Huang F# (2017) A light harvesting complex-like protein inmaintenance of photosynthetic components in Chlamydomonas. Plant Physiology, 174: 2419-2433

3. Chen M, Zhang J, Zhao L, Xing JL, Peng LW, Kuang TY, Rochaix JD, Huang F# (2016) Loss of algal Proton Gradient Regulation 5 increases reactive oxygen species scavenging and H2 evolution. Journal of Integrative Plant Biology, 58: 943-946

2. Yang HM, Liao LB, Bo TT, Zhao L, Sun XW, Norling B, Huang F# (2014) Slr0151 in Synechocystis sp.PCC 6803 is required for efficient repair of photosystem II under high-light condition. Journal of Integrative Plant Biology, 56: 1136-1150

1. Zhao L*, Chen M*, Cheng DM, Yang HM, Sun YL, Zhou HY, Huang F# (2013) Different B-type methionine sulfoxide reductases in Chlamydomonas may protect the alga against high-light, sulfur-depletion or oxidative stress. Journal of Integrative Plant Biology, 55: 1053-1067

 

申请专利

22.  赵磊、葛同玲、赵伦强、程庭峰,一株桃色欧文氏菌2022TIBBST187及其应用,专利申请号:CN2023102264910

21.  赵磊、赵伦强、葛同玲、程庭峰,Admx基因作为正调控因子在桃色欧文氏中提高安吉菌素产量的应用,专利申请号:CN202310731643.2

20.  赵磊、陈方见、刘智永、郝那辉、侯余勇,微藻絮凝剂及采收微藻的方法,专利申请号:CN202211233679.X

19.  赵磊、葛铜铃、王庆、韩童,雨生红球藻发酵产虾青素方法,专利申请号:CN202211127577.X

18.  赵磊、程庭峰、葛同玲、赵伦强、杨作仁,一株多黏芽孢杆菌及其在农业领域的应用,专利申请号:CN202211405946

17.  赵磊、葛同玲、程庭峰、赵伦强、侯余勇,桃色欧文氏菌产安吉菌素的方法,专利授权号:ZL202310226524.1

16.  赵磊、程庭峰、葛同玲,一株生防深绿木霉及其在农业领域的应用,专利授权号:ZL2022107186754

15.  赵磊、葛同玲、程庭峰,一株贝莱斯芽孢杆菌及其在农业领域的应用,专利授权号:ZL2022107179430


承担科研项目情况:
  

国家重点研发项目课题、国家自然基金委面上项目、中国科学院择优支持项目、天津市合成生物技术创新能力提升行动等。


获奖及荣誉:
  

受邀担任Journal of Plant Sciences编委、Modern Agriculture创刊副编委、New Crops年编委等;所培养研究生获“国家奖学金”“校优秀研究生”“校级一等奖学金”等重要奖项,合作博士后获得“中国博士后国际交流计划人才引进”和“中国科学院特别研究助理”等项目资助。