论文题目_中文	Asymmetric Synthesis of Both Antipodes of β Hydroxy Nitriles and beta-Hydroxy Carboxylic Acids via Enzymatic Reduction or Sequential Reduction/Hydrolysis
第一作者:	Haribabu Ankati
摘要:	Use of isolated carbonyl reductases in the reduction of aromatic β-ketonitriles have completely eliminated the competing α-ethylation, which is often observed with whole cell biocatalysts. By choosing suitable recombinant carbonyl reductase, the reduction of β-ketonitriles afforded (R)- or (S)-β-hydroxy nitriles with excellent optical purity and yield. Subsequently, nitrilase-catalyzed hydrolysis of the obtained optically pure β-hydroxy nitriles led to the corresponding β-hydroxy carboxylic acids in high yields. More importantly, the sequential enzymatic reduction and hydrolysis could be carried out in “two-step-one-pot” fashion without the isolation of intermediates β-hydroxy nitriles, lowering the cost and minimizing the environmental impact. This allows ready access to both antipodes of chiral β-hydroxy nitriles and β-hydroxy carboxylic acids of pharmaceutical importance with excellent optical purity.
联系作者:	Dunming Zhu
页码:	1658-1662
期:	74
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发表年度:	2008
卷:	4
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刊物名称:	The Journal of Organic Chemistry
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论文类别:	SCI
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